Real-time Bidding (RTB) inventory buying for popunder/popup ads in real-time on impression basis through a programmatic on-the-spot auction is one of the best way to reach your targeted audience. Working with RTB allows you to get maximum coverage over a specific geo or region and ensure you reachout to masses.
RTB however is an affective tool when used by experts and not suggested for newbie.
RTB starts @ $0.50 CPM onwards.